His research interests include geographic information science and systems (GIS), advanced cyberinfrastructure and cyberGIS, complex environmental and geospatial problems, computational and data sciences, high-performance and distributed computing, and spatial analysis and modeling. He has received research funding from a number of U.S. federal agencies (e.g., CDC, DOE, EPA, NASA, NSF, USDA, and USGS) and industry; and served as Principal Investigator (PI) for more than $15 million competitive research grants, and co-PI and investigator for contributing to sponsored research supported with tens of millions of U.S. dollars. He pioneered cyberGIS and has led several multi-institution interdisciplinary projects to advance cyberGIS and related scientific problem solving in agriculture, bioenergy, emergency management, geography and spatial sciences, geosciences, and public health. He has published numerous peer-reviewed papers including articles in more than 20 journals.
He has served as an Action Editor of GeoInformatica, Associate Editor of SoftwareX, and guest editor or editorial board member for multiple other journals, book series and proceedings. He served on the University Consortium for Geographic Information Science (UCGIS) Board of Directors from 2009 to 2012, and President of UCGIS from 2016 to 2017. He is serving on the advisory board of the NSF Extreme Science and Engineering Discovery Environment (XSEDE) program. He is a current member of the Board on Earth Sciences and Resources of the U.S. National Academies of Sciences, Engineering, and Medicine.